Use of Vitek 2 Antimicrobial Susceptibility Profile To Identify mecC in Methicillin-Resistant Staphylococcus aureus

نویسندگان

  • Edward J. P. Cartwright
  • Gavin K. Paterson
  • Kathy E. Raven
  • Ewan M. Harrison
  • Theodore Gouliouris
  • Angela Kearns
  • Bruno Pichon
  • Giles Edwards
  • Robert L. Skov
  • Anders R. Larsen
  • Mark A. Holmes
  • Julian Parkhill
  • Sharon J. Peacock
  • M. Estée Török
چکیده

The emergence of mecC methicillin-resistant Staphylococcus aureus (MRSA) poses a diagnostic challenge for clinical microbiology laboratories. Using the Vitek 2 system, we tested a panel of 896 Staphylococcus aureus isolates and found that an oxacillin-sensitive/cefoxitin-resistant profile had a sensitivity of 88.7% and a specificity of 99.5% for the identification of mecC MRSA isolates. The presence of the mecC gene, determined by bacterial whole-genome sequencing, was used as the gold standard. This profile could provide a zero-cost screening method for identification of mecC-positive MRSA strains.

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عنوان ژورنال:

دوره 51  شماره 

صفحات  -

تاریخ انتشار 2013